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Substitution of Arginine with Proline and Proline Derivatives in Melanocyte-Stimulating Hormones Leads to Selectivity for Human Melanocortin 4 Receptor
A new series of melanotropin analogues with His or Arg residues in the core pharmacophores of MTII, SHU9119 and Ac-NDP-γ-MSH-NH(2) replaced by Pro or trans-/cis- 4-guanidinyl-Pro derivatives were designed and synthesized to introduce selectivity toward the human melanocortin 4 receptor (hMC4R). Anal...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775485/ https://ncbi.nlm.nih.gov/pubmed/19473029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801300c |
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