Key amino acid residues in the Melanocortin-4 Receptor for nonpeptide THIQ Specific Binding and Signaling

Melanocortin 4 receptor (MC4R) plays an important role in the regulation of food intake and glucose homeostasis. Synthetic nonpeptide compound N- (3R)-1 4-tetrahydroisoquinolinium-3-ylcarbonyl -(1R)-1-(4-chlorobenzyl)-2- 4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl -2-oxoethylamine (TH...

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Main Authors: Yang, Yingkui, Cai, Minying, Chen, Min, Qu, Hongchang, McPherson, David, Hruby, Victor, Harmon, Carroll M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216638/
https://ncbi.nlm.nih.gov/pubmed/19303903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.regpep.2009.03.006
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