Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

PKD2 and PKD1 genes are mutated in human autosomal dominant polycystic kidney disease. PKD2 can form either a homomeric cation channel or a heteromeric complex with the PKD1 receptor, presumed to respond to ligand(s) and/or mechanical stimuli. Here, we identify a two-residue hydrophobic gate in PKD2...

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Publié dans:Nat Commun
Auteurs principaux: Zheng, Wang, Yang, Xiaoyong, Hu, Ruikun, Cai, Ruiqi, Hofmann, Laura, Wang, Zhifei, Hu, Qiaolin, Liu, Xiong, Bulkley, David, Yu, Yong, Tang, Jingfeng, Flockerzi, Veit, Cao, Ying, Cao, Erhu, Chen, Xing-Zhen
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998024/
https://ncbi.nlm.nih.gov/pubmed/29899465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04586-x
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