Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms largely unknown. We here revealed an intramolecular inter...

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Udgivet i:Cell Rep
Main Authors: Zheng, Wang, Cai, Ruiqi, Hofmann, Laura, Nesin, Vasyl, Hu, Qiaolin, Long, Wentong, Fatehi, Mohammad, Liu, Xiong, Hussein, Shaimaa, Kong, Tim, Li, Jingru, Light, Peter E., Tang, Jingfeng, Flockerzi, Veit, Tsiokas, Leonidas, Chen, Xing-Zhen
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483072/
https://ncbi.nlm.nih.gov/pubmed/29425510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.042
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