Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms largely unknown. We here revealed an intramolecular inter...

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Publicado no:Cell Rep
Main Authors: Zheng, Wang, Cai, Ruiqi, Hofmann, Laura, Nesin, Vasyl, Hu, Qiaolin, Long, Wentong, Fatehi, Mohammad, Liu, Xiong, Hussein, Shaimaa, Kong, Tim, Li, Jingru, Light, Peter E., Tang, Jingfeng, Flockerzi, Veit, Tsiokas, Leonidas, Chen, Xing-Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483072/
https://ncbi.nlm.nih.gov/pubmed/29425510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.042
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