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The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

The Polycystic Kidney Disease 2 (pkd2) gene is mutated in autosomal dominant polycystic kidney disease (ADPKD), one of the most common human monogenic disorders. Here, we present the cryo-EM structure of PKD2 in lipid bilayers at 3.0 Å resolution, which establishes PKD2 as a homotetrameric ion chann...

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Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Shen, Peter S., Yang, Xiaoyong, DeCaen, Paul G., Liu, Xiaowen, Bulkley, David, Clapham, David E., Cao, Erhu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055481/
https://ncbi.nlm.nih.gov/pubmed/27768895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.09.048
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