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The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs
The Polycystic Kidney Disease 2 (pkd2) gene is mutated in autosomal dominant polycystic kidney disease (ADPKD), one of the most common human monogenic disorders. Here, we present the cryo-EM structure of PKD2 in lipid bilayers at 3.0 Å resolution, which establishes PKD2 as a homotetrameric ion chann...
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| Yayımlandı: | Cell |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6055481/ https://ncbi.nlm.nih.gov/pubmed/27768895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.09.048 |
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