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Structure of the human TRPM4 ion channel in a lipid nanodisc

Transient receptor potential (TRP) melastatin 4 (TRPM4) is a widely expressed cation channel associated with a variety of cardiovascular disorders. TRPM4 is activated by increased intracellular calcium in a voltage dependent manner, but unlike many other TRP channels is permeable to monovalent catio...

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Foilsithe in:Science
Main Authors: Autzen, Henriette E., Myasnikov, Alexander G., Campbell, Melody G., Asarnow, Daniel, Julius, David, Cheng, Yifan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898196/
https://ncbi.nlm.nih.gov/pubmed/29217581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar4510
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