Paracrine co-delivery of TGF-β and IL-2 using CD4-targeted nanoparticles for induction and maintenance of regulatory T cells

The cytokine milieu is critical for orchestration of lineage development towards effector T cell (Teff) or regulatory T cell (Treg) subsets implicated in the progression of cancer and autoimmune disease. Importantly, the fitness and survival of the Treg subset is dependent on the cytokines Interleuk...

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Publicado en:Biomaterials
Main Authors: McHugh, Michael D., Park, Jason, Uhrich, Ross, Gao, Wenda, Horwitz, David A., Fahmy, Tarek M.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997248/
https://ncbi.nlm.nih.gov/pubmed/25974747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.04.003
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