An Artificial Antigen-presenting Cell with Paracrine Delivery of IL-2 Impacts the Magnitude and Direction of the T Cell Response

Artificial antigen-presenting cells (aAPCs) are an emerging technology to induce therapeutic cellular immunity without the need for autologous antigen-presenting cells (APCs). To fully replace natural APCs, an optimized aAPC must present antigen (signal 1), provide costimulation (signal 2), and rele...

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Detalhes bibliográficos
Main Authors: Steenblock, Erin R., Fadel, Tarek, Labowsky, Michael, Pober, Jordan S., Fahmy, Tarek M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186438/
https://ncbi.nlm.nih.gov/pubmed/21849500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276329
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