Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity

Here we report a “configuration-dependent” mechanism of action for IL-15:IL-15Rα (heterodimeric IL-15 or hetIL-15) where the manner by which IL-15:IL-15Rα molecules are presented to target cells significantly affects its function as a vaccine adjuvant. Although the cellular mechanism of IL-15 trans-...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hong, Enping, Usiskin, Ilana M., Bergamaschi, Cristina, Hanlon, Douglas J., Edelson, Richard L., Justesen, Sune, Pavlakis, George N., Flavell, Richard A., Fahmy, Tarek M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861462/
https://ncbi.nlm.nih.gov/pubmed/26719339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695304
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