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Suppression of Murine Lupus by CD4(+) and CD8(+) T Regulatory Cells Induced by T-Cell Targeted Nanoparticles Loaded with IL-2 and TGF-β
OBJECTIVE: To develop a nanoparticle platform that can expand both CD4(+) and CD8(+) T regulatory cells (Tregs) in vivo for the suppression of autoimmune responses in systemic lupus erythematosus (SLE). METHODS: Poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) encapsulating IL-2 and TGF-β we...
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| Publicado no: | Arthritis Rheumatol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6438734/ https://ncbi.nlm.nih.gov/pubmed/30407752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40773 |
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