Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism

We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4(+) T cells from DBA/2 mice into (C57BL/6 × DBA/2)F(1) (BDF1) mice. Although the protective effects were ascribed...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Horwitz, David A., Liu, Aijing, Bickerton, Sean, Castaldo, Giuseppe, Matarese, Giuseppe, Fahmy, Tarek M., La Cava, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772200/
https://ncbi.nlm.nih.gov/pubmed/33391260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.583338
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