Staphylococcus aureus Phenol-Soluble Modulins α1–α3 Act as Novel Toll-Like Receptor (TLR) 4 Antagonists to Inhibit HMGB1/TLR4/NF-κB Signaling Pathway

Phenol-soluble modulins (PSMs) have recently emerged as key virulence determinants, particularly in highly aggressive Staphylococcus aureus isolates. These peptides contribute to the pathogenesis of S. aureus infections, participating in multiple inflammatory responses. Here, we report a new role fo...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Chu, Ming, Zhou, Mingya, Jiang, Caihong, Chen, Xi, Guo, Likai, Zhang, Mingbo, Chu, Zhengyun, Wang, Yuedan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996891/
https://ncbi.nlm.nih.gov/pubmed/29922279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00862
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