Staphylococcus aureus Phenol-Soluble Modulins α1–α3 Act as Novel Toll-Like Receptor (TLR) 4 Antagonists to Inhibit HMGB1/TLR4/NF-κB Signaling Pathway

Phenol-soluble modulins (PSMs) have recently emerged as key virulence determinants, particularly in highly aggressive Staphylococcus aureus isolates. These peptides contribute to the pathogenesis of S. aureus infections, participating in multiple inflammatory responses. Here, we report a new role fo...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Chu, Ming, Zhou, Mingya, Jiang, Caihong, Chen, Xi, Guo, Likai, Zhang, Mingbo, Chu, Zhengyun, Wang, Yuedan
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996891/
https://ncbi.nlm.nih.gov/pubmed/29922279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00862
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