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Toll-like Receptor 4 (TLR4) Antagonist Eritoran Tetrasodium Attenuates Liver Ischemia and Reperfusion Injury through Inhibition of High-Mobility Group Box Protein B1 (HMGB1) Signaling

Toll-like receptor 4 (TLR4) is ubiquitously expressed on parenchymal and immune cells of the liver and is the most studied TLR responsible for the activation of proinflammatory signaling cascades in liver ischemia and reperfusion (I/R). Since pharmacological inhibition of TLR4 during the sterile inf...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: McDonald, Kerry-Ann, Huang, Hai, Tohme, Samer, Loughran, Patricia, Ferrero, Kimberly, Billiar, Timothy, Tsung, Allan
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365061/
https://ncbi.nlm.nih.gov/pubmed/25375408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2014.00076
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