Insight into structure-function relationship in phenol-soluble modulins using an alanine screen of the phenol-soluble modulin (PSM) α3 peptide

Phenol-soluble modulins (PSMs) are a family of peptides with multiple functions in staphylococcal pathogenesis. To gain insight into the structural features affecting PSM functions, we analyzed an alanine substitution library of PSMα3, a strongly cytolytic and proinflammatory PSM of Staphylococcus a...

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Autors principals: Cheung, Gordon Y. C., Kretschmer, Dorothee, Queck, Shu Y., Joo, Hwang-Soo, Wang, Rong, Duong, Anthony C., Nguyen, Thuan H., Bach, Thanh-Huy L., Porter, Adeline R., DeLeo, Frank R., Peschel, Andreas, Otto, Michael
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2014
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868839/
https://ncbi.nlm.nih.gov/pubmed/24008753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-232041
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