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Conjugate Polyplexes with Anti-Invasive Properties and Improved siRNA Delivery In Vivo

This study reports on a simple method to prepare siRNA-polycation conjugate polyplexes by in situ thiol-disulfide exchange reaction. The conjugate polyplexes are prepared using thiol-terminated siRNA and a bioreducible branched polycationic inhibitor of the CXCR4 chemokine receptor (rPAMD). The rPAM...

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書目詳細資料
發表在:Bioconjug Chem
Main Authors: Chen, Yi, Li, Jing, Oupický, David
格式: Artigo
語言:Inglês
出版: 2018
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5996769/
https://ncbi.nlm.nih.gov/pubmed/29338191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00622
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