Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

Achieving efficient in vivo delivery of siRNA to the appropriate target cell would be a major advance in the use of RNAi in gene function studies and as a therapeutic modality. Hepatocytes, the key parenchymal cells of the liver, are a particularly attractive target cell type for siRNA delivery give...

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Bibliografiska uppgifter
Huvudupphovsmän: Rozema, David B., Lewis, David L., Wakefield, Darren H., Wong, So C., Klein, Jason J., Roesch, Paula L., Bertin, Stephanie L., Reppen, Tom W., Chu, Qili, Blokhin, Andrei V., Hagstrom, James E., Wolff, Jon A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2007
Ämnen:
Physical Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941806/
https://ncbi.nlm.nih.gov/pubmed/17652171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703778104
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