Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

Achieving efficient in vivo delivery of siRNA to the appropriate target cell would be a major advance in the use of RNAi in gene function studies and as a therapeutic modality. Hepatocytes, the key parenchymal cells of the liver, are a particularly attractive target cell type for siRNA delivery give...

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Main Authors: Rozema, David B., Lewis, David L., Wakefield, Darren H., Wong, So C., Klein, Jason J., Roesch, Paula L., Bertin, Stephanie L., Reppen, Tom W., Chu, Qili, Blokhin, Andrei V., Hagstrom, James E., Wolff, Jon A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Physical Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941806/
https://ncbi.nlm.nih.gov/pubmed/17652171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703778104
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