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Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation

Most eukaryotic genes express alternative polyadenylation (APA) isoforms with different 3′UTR lengths, production of which is influenced by cellular conditions. Here, we show that arsenic stress elicits global shortening of 3′UTRs through preferential usage of proximal polyadenylation sites during s...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Zheng, Dinghai, Wang, Ruijia, Ding, Qingbao, Wang, Tianying, Xie, Bingning, Wei, Lu, Zhong, Zhaohua, Tian, Bin
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995920/
https://ncbi.nlm.nih.gov/pubmed/29891946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04730-7
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