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Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation
Most eukaryotic genes express alternative polyadenylation (APA) isoforms with different 3′UTR lengths, production of which is influenced by cellular conditions. Here, we show that arsenic stress elicits global shortening of 3′UTRs through preferential usage of proximal polyadenylation sites during s...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5995920/ https://ncbi.nlm.nih.gov/pubmed/29891946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04730-7 |
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