Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins

Cotranslational protein folding can facilitate rapid formation of functional structures. However, it might also cause premature assembly of protein complexes, if two interacting nascent chains are in close proximity. By analyzing known protein structures, we show that homomeric protein contacts are...

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Vydáno v:Nat Struct Mol Biol
Hlavní autoři: Natan, Eviatar, Endoh, Tamaki, Haim-Vilmovsky, Liora, Flock, Tilman, Chalancon, Guilhem, Hopper, Jonathan TS., Kintses, Bálint, Horvath, Peter, Daruka, Lejla, Fekete, Gergely, Pál, Csaba, Papp, Balázs, Őszi, Erika, Magyar, Zoltán, Marsh, Joseph A., Elcock, Adrian H., Babu, M Madan, Robinson, Carol V., Sugimoto, Naoki, Teichmann, Sarah A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995306/
https://ncbi.nlm.nih.gov/pubmed/29434345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0029-5
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