Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins

Cotranslational protein folding can facilitate rapid formation of functional structures. However, it might also cause premature assembly of protein complexes, if two interacting nascent chains are in close proximity. By analyzing known protein structures, we show that homomeric protein contacts are...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Natan, Eviatar, Endoh, Tamaki, Haim-Vilmovsky, Liora, Flock, Tilman, Chalancon, Guilhem, Hopper, Jonathan TS., Kintses, Bálint, Horvath, Peter, Daruka, Lejla, Fekete, Gergely, Pál, Csaba, Papp, Balázs, Őszi, Erika, Magyar, Zoltán, Marsh, Joseph A., Elcock, Adrian H., Babu, M Madan, Robinson, Carol V., Sugimoto, Naoki, Teichmann, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995306/
https://ncbi.nlm.nih.gov/pubmed/29434345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0029-5
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