Activated matriptase as a target to treat breast cancer with a drug conjugate

The antitumor effects of a novel antibody drug conjugate (ADC) was tested against human solid tumor cell lines and against human triple negative breast cancer (TNBC) xenografts in immunosuppressed mice. The ADC targeting activated matriptase of tumor cells was synthesized by using the potent anti-tu...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Rather, Gulam M., Lin, Siang-Yo, Lin, Hongxia, Banach-Petrosky, Whitney, Hirshfield, Kim M., Lin, Chen-Yong, Johnson, Michael D., Szekely, Zoltan, Bertino, Joseph R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995259/
https://ncbi.nlm.nih.gov/pubmed/29899836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25414
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