Activated matriptase as a target to treat breast cancer with a drug conjugate

The antitumor effects of a novel antibody drug conjugate (ADC) was tested against human solid tumor cell lines and against human triple negative breast cancer (TNBC) xenografts in immunosuppressed mice. The ADC targeting activated matriptase of tumor cells was synthesized by using the potent anti-tu...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Rather, Gulam M., Lin, Siang-Yo, Lin, Hongxia, Banach-Petrosky, Whitney, Hirshfield, Kim M., Lin, Chen-Yong, Johnson, Michael D., Szekely, Zoltan, Bertino, Joseph R.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995259/
https://ncbi.nlm.nih.gov/pubmed/29899836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25414
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