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Cas4 nucleases define the PAM, length, and orientation of DNA fragments integrated at CRISPR loci
To achieve adaptive and heritable immunity against viruses and other mobile genetic elements, CRISPR-Cas systems must capture and store short DNA fragments (spacers) from these foreign elements into host genomic CRISPR arrays. This process is catalyzed by conserved Cas1/Cas2 integration complexes, b...
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| Veröffentlicht in: | Mol Cell |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5994930/ https://ncbi.nlm.nih.gov/pubmed/29883605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.002 |
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