Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder

CDKL5 disorder is a severe neurodevelopmental disorder caused by mutations in the X-linked CDKL5 (cyclin-dependent kinase-like five) gene. CDKL5 disorder primarily affects girls and is characterized by early-onset epileptic seizures, gross motor impairment, intellectual disability, and autistic feat...

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Vydáno v:Neural Plast
Hlavní autoři: Fuchs, Claudia, Gennaccaro, Laura, Trazzi, Stefania, Bastianini, Stefano, Bettini, Simone, Lo Martire, Viviana, Ren, Elisa, Medici, Giorgio, Zoccoli, Giovanna, Rimondini, Roberto, Ciani, Elisabetta
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994305/
https://ncbi.nlm.nih.gov/pubmed/29977282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/9726950
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