CRISPR-FRT targets shared sites in a knock-out collection for off-the-shelf genome editing

CRISPR advances genome engineering by directing endonuclease sequence specificity with a guide RNA molecule (gRNA). For precisely targeting a gene for modification, each genetic construct requires a unique gRNA. By generating a gRNA against the flippase recognition target (FRT) site, a common geneti...

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Publicat a:Nat Commun
Autors principals: Swings, Toon, Marciano, David C., Atri, Benu, Bosserman, Rachel E., Wang, Chen, Leysen, Marlies, Bonte, Camille, Schalck, Thomas, Furey, Ian, Van den Bergh, Bram, Verstraeten, Natalie, Christie, Peter J., Herman, Christophe, Lichtarge, Olivier, Michiels, Jan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993718/
https://ncbi.nlm.nih.gov/pubmed/29884781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04651-5
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