Učitavanje...
CRISPR/Cas9 Gene editing of RyR2 in human stem cell-derived cardiomyocytes provides a novel approach in investigating dysfunctional Ca(2+) signaling
Type-2 ryanodine receptors (RyR2s) play a pivotal role in cardiac excitation-contraction coupling by releasing Ca(2+) from sarcoplasmic reticulum (SR) via a Ca(2+) -induced Ca(2+) release (CICR) mechanism. Two strategies have been used to study the structure-function characteristics of RyR2 and its...
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| Izdano u: | Cell Calcium |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5993620/ https://ncbi.nlm.nih.gov/pubmed/29730419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2018.04.009 |
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