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CRISPR/Cas9 Gene editing of RyR2 in human stem cell-derived cardiomyocytes provides a novel approach in investigating dysfunctional Ca(2+) signaling

Type-2 ryanodine receptors (RyR2s) play a pivotal role in cardiac excitation-contraction coupling by releasing Ca(2+) from sarcoplasmic reticulum (SR) via a Ca(2+) -induced Ca(2+) release (CICR) mechanism. Two strategies have been used to study the structure-function characteristics of RyR2 and its...

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Detalhes bibliográficos
Publicado no:Cell Calcium
Main Authors: Wei, Hua, Zhang, Xiao-Hua, Clift, Cassandra, Yamaguchi, Naohiro, Morad, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993620/
https://ncbi.nlm.nih.gov/pubmed/29730419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2018.04.009
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