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Differential strengths of molecular determinants guide environment specific mutational fates

Organisms maintain competitive fitness in the face of environmental challenges through molecular evolution. However, it remains largely unknown how different biophysical factors constrain molecular evolution in a given environment. Here, using deep mutational scanning, we quantified empirical fitnes...

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Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Dandage, Rohan, Pandey, Rajesh, Jayaraj, Gopal, Rai, Manish, Berger, David, Chakraborty, Kausik
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993328/
https://ncbi.nlm.nih.gov/pubmed/29813059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007419
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