Differential strengths of molecular determinants guide environment specific mutational fates

Organisms maintain competitive fitness in the face of environmental challenges through molecular evolution. However, it remains largely unknown how different biophysical factors constrain molecular evolution in a given environment. Here, using deep mutational scanning, we quantified empirical fitnes...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Dandage, Rohan, Pandey, Rajesh, Jayaraj, Gopal, Rai, Manish, Berger, David, Chakraborty, Kausik
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993328/
https://ncbi.nlm.nih.gov/pubmed/29813059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007419
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