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Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis

Metabolic changes alter the cellular milieu; can this also change intracellular protein folding? Since proteostasis can modulate mutational buffering, if change in metabolism has the ability to change protein folding, arguably, it should also alter mutational buffering. Here we find that altered cel...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Verma, Kanika, Saxena, Kanika, Donaka, Rajashekar, Chaphalkar, Aseem, Rai, Manish Kumar, Shukla, Anurag, Zaidi, Zainab, Dandage, Rohan, Shanmugam, Dhanasekaran, Chakraborty, Kausik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286901/
https://ncbi.nlm.nih.gov/pubmed/32522991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16804-6
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