Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis

Unfolded protein response (UPR) of the endoplasmic reticulum (UPR(ER)) helps maintain proteostasis in the cell. The ability to mount an effective UPR(ER) to external stress (iUPR(ER)) decreases with age and is linked to the pathophysiology of multiple age-related disorders. Here, we show that a tran...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Matai, Latika, Sarkar, Gautam Chandra, Chamoli, Manish, Malik, Yasir, Kumar, Shashi Shekhar, Rautela, Umanshi, Jana, Nihar Ranjan, Chakraborty, Kausik, Mukhopadhyay, Arnab
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717303/
https://ncbi.nlm.nih.gov/pubmed/31413197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900055116
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