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Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis
Unfolded protein response (UPR) of the endoplasmic reticulum (UPR(ER)) helps maintain proteostasis in the cell. The ability to mount an effective UPR(ER) to external stress (iUPR(ER)) decreases with age and is linked to the pathophysiology of multiple age-related disorders. Here, we show that a tran...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6717303/ https://ncbi.nlm.nih.gov/pubmed/31413197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900055116 |
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