Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson’s Disease Mouse Model

Parkinson’s disease (PD) is one of the most affected neurodegenerative diseases in the world. Deregulation of cyclin-dependent kinase 5 (Cdk5) is believed to play an important role in neurodegenerative diseases including PD. p25 is a cleavage peptide of p35, a physiologic activator of Cdk5. p25 comb...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Aging Neurosci
Prif Awduron: He, Rongni, Huang, Wei, Huang, Yaowei, Xu, Miaojing, Song, Pingping, Huang, Yinwei, Xie, Huifang, Hu, Yafang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992349/
https://ncbi.nlm.nih.gov/pubmed/29910724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00162
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