Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson’s Disease Mouse Model

Parkinson’s disease (PD) is one of the most affected neurodegenerative diseases in the world. Deregulation of cyclin-dependent kinase 5 (Cdk5) is believed to play an important role in neurodegenerative diseases including PD. p25 is a cleavage peptide of p35, a physiologic activator of Cdk5. p25 comb...

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Udgivet i:Front Aging Neurosci
Main Authors: He, Rongni, Huang, Wei, Huang, Yaowei, Xu, Miaojing, Song, Pingping, Huang, Yinwei, Xie, Huifang, Hu, Yafang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992349/
https://ncbi.nlm.nih.gov/pubmed/29910724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00162
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