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Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity
The lysosomal cysteine protease Cathepsin K is elevated in humans and animal models of heart failure. Our recent studies show that whole-body deletion of Cathepsin K protects mice against cardiac dysfunction. Whether this is attributable to a direct effect on cardiomyocytes or is a consequence of th...
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| Publicado no: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5992138/ https://ncbi.nlm.nih.gov/pubmed/29880809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0727-2 |
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