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CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes

A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Zhou, Yujing, Engl, Oliver D., Bandar, Jeffrey S., Chant, Emma D., Buchwald, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992098/
https://ncbi.nlm.nih.gov/pubmed/29660768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201802797
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