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Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis

[Image: see text] Detailed in this Communication is the enantioselective synthesis of 1,1-diarylalkanes, a structure found in a range of pharmaceutical drug agents and natural products, through the employment of copper(I) hydride and palladium catalysis. Judicious choice of ligand for both Cu and Pd...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Friis, Stig D., Pirnot, Michael T., Buchwald, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010014/
https://ncbi.nlm.nih.gov/pubmed/27346525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b04566
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