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A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys

BACKGROUND: PDE10A is a member of the phosphodiesterase family whose brain expression is restricted to the striatum. PDE10A regulates cAMP and cGMP, which mediate responses to dopamine receptor activation, and the levels of these cyclic nucleotides are decreased in experimental models of L-Dopa-indu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mov Disord
Prif Awduron: Beck, Goichi, Maehara, Shunsuke, Chang, Phat Ly, Papa, Stella M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992016/
https://ncbi.nlm.nih.gov/pubmed/29508924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27341
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