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A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys

BACKGROUND: PDE10A is a member of the phosphodiesterase family whose brain expression is restricted to the striatum. PDE10A regulates cAMP and cGMP, which mediate responses to dopamine receptor activation, and the levels of these cyclic nucleotides are decreased in experimental models of L-Dopa-indu...

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書目詳細資料
發表在:Mov Disord
Main Authors: Beck, Goichi, Maehara, Shunsuke, Chang, Phat Ly, Papa, Stella M.
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992016/
https://ncbi.nlm.nih.gov/pubmed/29508924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27341
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