L-Dopa induced dyskinesias in Parkinsonian mice: disease severity or L-Dopa history

In Parkinson's disease, the efficacy of L-Dopa treatment changes over time, as dyskinesias emerge with previously beneficial doses. Using MitoPark mice, that models mitochondrial failure in dopamine (DA) neurons and mimics the progressive loss of dopamine observed in Parkinson’s disease, we fou...

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Bibliografiska uppgifter
I publikationen:Brain Res
Huvudupphovsmän: Shan, Lufei, Diaz, Oscar, Zhang, Yajun, Ladenheim, Bruce, Cadet, Jean-Lud, Chiang, Yung-Hsiao, Olson, Lars, Hoffer, Barry J., Bäckman, Cristina M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710145/
https://ncbi.nlm.nih.gov/pubmed/26086365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2015.06.005
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