L-Dopa induced dyskinesias in Parkinsonian mice: disease severity or L-Dopa history

In Parkinson's disease, the efficacy of L-Dopa treatment changes over time, as dyskinesias emerge with previously beneficial doses. Using MitoPark mice, that models mitochondrial failure in dopamine (DA) neurons and mimics the progressive loss of dopamine observed in Parkinson’s disease, we fou...

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Bibliographic Details
Published in:Brain Res
Main Authors: Shan, Lufei, Diaz, Oscar, Zhang, Yajun, Ladenheim, Bruce, Cadet, Jean-Lud, Chiang, Yung-Hsiao, Olson, Lars, Hoffer, Barry J., Bäckman, Cristina M.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710145/
https://ncbi.nlm.nih.gov/pubmed/26086365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2015.06.005
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