Enhanced striatal cholinergic neuronal activity mediates l-DOPA–induced dyskinesia in parkinsonian mice

Treatment of Parkinson disease (PD) with l-3,4-dihydroxyphenylalanine (l-DOPA) dramatically relieves associated motor deficits, but l-DOPA–induced dyskinesias (LID) limit the therapeutic benefit over time. Previous investigations have noted changes in striatal medium spiny neurons, including abnorma...

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Main Authors: Ding, Yunmin, Won, Lisa, Britt, Jonathan P., Lim, Sean Austin O., McGehee, Daniel S., Kang, Un Jung
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021072/
https://ncbi.nlm.nih.gov/pubmed/21187382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006511108
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