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Enhanced striatal cholinergic neuronal activity mediates l-DOPA–induced dyskinesia in parkinsonian mice
Treatment of Parkinson disease (PD) with l-3,4-dihydroxyphenylalanine (l-DOPA) dramatically relieves associated motor deficits, but l-DOPA–induced dyskinesias (LID) limit the therapeutic benefit over time. Previous investigations have noted changes in striatal medium spiny neurons, including abnorma...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3021072/ https://ncbi.nlm.nih.gov/pubmed/21187382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006511108 |
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