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A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys
BACKGROUND: PDE10A is a member of the phosphodiesterase family whose brain expression is restricted to the striatum. PDE10A regulates cAMP and cGMP, which mediate responses to dopamine receptor activation, and the levels of these cyclic nucleotides are decreased in experimental models of L-Dopa-indu...
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| 出版年: | Mov Disord |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5992016/ https://ncbi.nlm.nih.gov/pubmed/29508924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27341 |
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