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Frequent sgRNA-barcode recombination in single-cell perturbation assays
Simultaneously detecting CRISPR-based perturbations and induced transcriptional changes in the same cell is a powerful approach to unraveling genome function. Several lentiviral approaches have been developed, some of which rely on the detection of distally located genetic barcodes as an indirect pr...
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| Опубликовано в: : | PLoS One |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5991360/ https://ncbi.nlm.nih.gov/pubmed/29874289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198635 |
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