Rhodium Catalyzed Asymmetric Hydrogenation of Unprotected N-H Imines Assisted by Thiourea()

Asymmetric hydrogenation of unprotected N-H imines catalyzed by Rh/bisphosphine-thiourea provided chiral amines with up to 97% yield and 95% ee. (1)H NMR studies, coupled with control experiments, implied that catalytic chloride-bound intermediates were involved in the mechanism via the dual hydroge...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Zhao, Qingyang, Wen, Jialin, Tan, Renchang, Huang, Kexuan, Metola, Pedro, Wang, Rui, Anslyn, Eric V., Zhang, Xumu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989712/
https://ncbi.nlm.nih.gov/pubmed/24939397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201404570
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