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Rhodium-catalyzed asymmetric hydrogenation of β-cyanocinnamic esters with the assistance of a single hydrogen bond in a precise position

With the assistance of hydrogen bonds, the first asymmetric hydrogenation of β-cyanocinnamic esters is developed, affording chiral β-cyano esters with excellent enantioselectivities (up to 99% ee). This novel methodology provides an efficient and concise synthetic route to chiral GABA-derivatives su...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Li, Xiuxiu, You, Cai, Yang, Yusheng, Yang, Yuhong, Li, Pan, Gu, Guoxian, Chung, Lung Wa, Lv, Hui, Zhang, Xumu
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890790/
https://ncbi.nlm.nih.gov/pubmed/29675238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc04639a
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