TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity

NAFLD is a clinically progressive disease with steatosis, inflammation, endothelial dysfunction and fibrosis being the stages where clinical intervention becomes necessary. Lack of early biomarkers and absence of a FDA approved drug obstructs efforts for effective treatment. NAFLD progression is str...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Seth, Ratanesh K., Das, Suvarthi, Dattaroy, Diptadip, Chandrashekaran, Varun, Alhasson, Firas, Michelotti, Gregory, Nagarkatti, Mitzi, Nagarkatti, Prakash, Diehl, Anna Mae, Bell, P. Darwin, Liedtke, Wolfgang, Chatterjee, Saurabh
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989309/
https://ncbi.nlm.nih.gov/pubmed/27913210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.11.047
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