Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice

The balance between synthesis and degradation of the cartilage extracellular matrix is severely altered in osteoarthritis, where degradation predominates. One reason for this imbalance is believed to be due to the ligation of the α5β1 integrin, the classic fibronectin (FN) receptor, with soluble FN...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Almonte-Becerril, Maylin, Gimeno-LLuch, Irene, Villarroya, Olga, Benito-Jardón, María, Kouri, Juan Bautista, Costell, Mercedes
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988303/
https://ncbi.nlm.nih.gov/pubmed/29870552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198559
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