Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice

The balance between synthesis and degradation of the cartilage extracellular matrix is severely altered in osteoarthritis, where degradation predominates. One reason for this imbalance is believed to be due to the ligation of the α5β1 integrin, the classic fibronectin (FN) receptor, with soluble FN...

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Vydáno v:PLoS One
Hlavní autoři: Almonte-Becerril, Maylin, Gimeno-LLuch, Irene, Villarroya, Olga, Benito-Jardón, María, Kouri, Juan Bautista, Costell, Mercedes
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988303/
https://ncbi.nlm.nih.gov/pubmed/29870552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198559
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