Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice

The balance between synthesis and degradation of the cartilage extracellular matrix is severely altered in osteoarthritis, where degradation predominates. One reason for this imbalance is believed to be due to the ligation of the α5β1 integrin, the classic fibronectin (FN) receptor, with soluble FN...

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Veröffentlicht in:PLoS One
Hauptverfasser: Almonte-Becerril, Maylin, Gimeno-LLuch, Irene, Villarroya, Olga, Benito-Jardón, María, Kouri, Juan Bautista, Costell, Mercedes
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988303/
https://ncbi.nlm.nih.gov/pubmed/29870552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198559
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